Novel strategies for the construction of cyclic boronate esters and acids & novel aspects of furan chemistry

Methodology studies for cyclic boronate ester synthesis Figure i: Target molecules (see Abstract in pdf for image) Structures i,ii,iii represent a general depiction of cyclic boron-containing heterocyles targeted in this methodology study. These molecules will be made using a range of new organic pathways. A 1,3 nitrogen-boron relationship in selected structures will also be investigated due to its importance in pharmaceutical chemistry. In the pursuit of cyclic boranes a new method for the preparation of unsaturated ketones has been discovered, which utilises the boron chemistry outlined below. Figure ii: Reagents and Conditions: (a) tBuLi, B(OIPr)3, Et2O, -79 °C, 20 % (see Abstract in pdf for image) Novel aspects of furan chemistry It was found that the furan derivative vii, when treated with palladium salts, gave the bis-annulated benzene structure viii. This sequence gave rise to a novel method for the construction of aromatic rings. This reaction was tested on a range of substituted furans in order to examine the scope of this reaction. Figure iii: Reagents and Conditions: (a) Pd(OAc)2, K2CO3, MeCN, 80 °C, 25% (see Abstract in pdf for image

Re-Creating Organizational Routines to Transition Through the Project Life Cycle: A Case Study of the Reconstruction of London’s Bank Underground Station

This article provides new insights into the project life cycle by proposing an alternative image to the predefined time boundary between life cycle stages. It makes a theoretical contribution by identifying how project organizations re-create patterns of action—organizational routines—as they transition through life cycle stages. It presents the findings of an autoethnographic empirical study and, through the lens of routine dynamics, contributes to the project management literature by identifying a five-stage process model of transitioning and the generative mechanisms involved in re-creating patterns of action

A mismatch between institutional conditions and trust

In this study, we aim to unpack why information conveyed by high-status women are less trusted in the collaborative project setting. We theorize about the mechanism of gender-status mismatch - a cultural-cognitive mismatch between beliefs about gender and status hierarchies when a woman is associated with the high status. We set three hypotheses to test the negative effects of the mismatch on trust in women: (1) a woman who has a higher rank is considered a mismatch, (2) a woman who works for a high-status organization is considered a mismatch, and (3) a woman who has a higher network status is considered a mismatch

Cosmological Parameter Extraction from the First Season of Observations with DASI

The Degree Angular Scale Interferometer (\dasi) has measured the power spectrum of the Cosmic Microwave Background anisotropy over the range of spherical harmonic multipoles 100<l<900. We compare this data, in combination with the COBE-DMR results, to a seven dimensional grid of adiabatic CDM models. Adopting the priors h>0.45 and 0.0<=tau_c<=0.4, we find that the total density of the Universe Omega_tot=1.04+/-0.06, and the spectral index of the initial scalar fluctuations n_s=1.01+0.08-0.06, in accordance with the predictions of inflationary theory. In addition we find that the physical density of baryons Omega_b.h^2=0.022+0.004-0.003, and the physical density of cold dark matter Omega_cdm.h^2=0.14+/-0.04. This value of Omega_b.h^2 is consistent with that derived from measurements of the primordial abundance ratios of the light elements combined with big bang nucleosynthesis theory. Using the result of the HST Key Project h=0.72+/-0.08 we find that Omega_t=1.00+/-0.04, the matter density Omega_m=0.40+/-0.15, and the vacuum energy density Omega_lambda=0.60+/-0.15. (All 68% confidence limits.)Comment: 7 pages, 4 figures, minor changes in response to referee comment

CMB constraints on spatial variations of the vacuum energy density

In a recent article, a simple `spherical bubble' toy model for a spatially varying vacuum energy density was introduced, and type Ia supernovae data was used to constrain it. Here we generalize the model to allow for the fact that we may not necessarily be at the centre of a region with a given set of cosmological parameters, and discuss the constraints on these models coming from Cosmic Microwave Background Radiation data. We find tight constraints on possible spatial variations of the vacuum energy density for any significant deviations from the centre of the bubble and we comment on the relevance of our results.Comment: Minor changes; to appear in Astroparticle Physic

Brane Dynamics in the Randall-Sundrum model, Inflation and Graceful Exit

We study the averaged action of the Randall-Sundrum model with a time dependent metric ansatz. It can be reformulated in terms of a Brans-Dicke action with time dependent Newton's constant. We show that the physics of early universe, particularly inflation, is governed by the Brans-Dicke theory. The Brans-Dicke scalar, however, quickly settles to its equilibrium value and decouples from the post-inflationary cosmology. The deceleration parameter is negative to start with but changes sign before the Brans-Dicke scalar settles to its equilibrium value. Consequently, the brane metric smoothly exits inflation. We have also studied the slow-roll inflation in our model and investigated the spectra of the density perturbation generated by the radion field and find them consistent with the current observations.Comment: Revised version, Accepted in Class. Quant. Gravit

DASI First Results: A Measurement of the Cosmic Microwave Background Angular Power Spectrum

We present measurements of anisotropy in the Cosmic Microwave Background (CMB) from the first season of observations with the Degree Angular Scale Interferometer (DASI). The instrument was deployed at the South Pole in the austral summer 1999--2000, and made observations throughout the following austral winter. We have measured the angular power spectrum of the CMB in the range 100<l<900 with high signal-to-noise. In this paper we review the formalism used in the analysis, in particular the use of constraint matrices to project out contaminants such as ground and point source signals, and to test for correlations with diffuse foreground templates. We find no evidence of foregrounds other than point sources in the data, and find a maximum likelihood temperature spectral index beta = -0.1 +/- 0.2 (1 sigma), consistent with CMB. We detect a first peak in the power spectrum at l approx 200, in agreement with previous experiments. In addition, we detect a peak in the power spectrum at l approx 550 and power of similar magnitude at l approx 800 which are consistent with the second and third harmonic peaks predicted by adiabatic inflationary cosmological models.Comment: 8 pages, 1 figure, minor changes in response to referee comment

Ethical issues in the use of in-depth interviews: literature review and discussion

This paper reports a literature review on the topic of ethical issues in in-depth interviews. The review returned three types of article: general discussion, issues in particular studies, and studies of interview-based research ethics. Whilst many of the issues discussed in these articles are generic to research ethics, such as confidentiality, they often had particular manifestations in this type of research. For example, privacy was a significant problem as interviews sometimes probe unexpected areas. For similar reasons, it is difficult to give full information of the nature of a particular interview at the outset, hence informed consent is problematic. Where a pair is interviewed (such as carer and cared-for) there are major difficulties in maintaining confidentiality and protecting privacy. The potential for interviews to harm participants emotionally is noted in some papers, although this is often set against potential therapeutic benefit. As well as these generic issues, there are some ethical issues fairly specific to in-depth interviews. The problem of dual role is noted in many papers. It can take many forms: an interviewer might be nurse and researcher, scientist and counsellor, or reporter and evangelist. There are other specific issues such as taking sides in an interview, and protecting vulnerable groups. Little specific study of the ethics of in-depth interviews has taken place. However, that which has shows some important findings. For example, one study shows participants are not averse to discussing painful issues provided they feel the study is worthwhile. Some papers make recommendations for researchers. One such is that they should consider using a model of continuous (or process) consent rather than viewing consent as occurring once, at signature, prior to the interview. However, there is a need for further study of this area, both philosophical and empirical

Lower Limits on Soft Supersymmetry-Breaking Scalar Masses

Working in the context of the CMSSM, we argue that phenomenological constraints now require the universal soft supersymmetry-breaking scalar mass m_0 be non-zero at the input GUT scale. This conclusion is primarily imposed by the LEP lower limit on the Higgs mass and the requirement that the lightest supersymmetric particle not be charged. We find that m_0 > 0 for all tan beta if mu 0 only when tan beta sim 8 and one allows an uncertainty of 3+ GeV in the theoretical calculation of the Higgs mass. Upper limits on flavour-changing neutral interactions in the MSSM squark sector allow substantial violations of non-universality in the m_0 values, even if their magnitudes are comparable to the lower limit we find in the CMSSM. Also, we show that our lower limit on m_0 at the GUT scale in the CMSSM is compatible with the no-scale boundary condition m_0 = 0 at the Planck scale.Comment: 11 pages, latex, 6 eps figure

Visualising high-dimensional Pareto relationships in two-dimensional scatterplots

Copyright © 2013 Springer-Verlag Berlin Heidelberg. The final publication is availablevia the DOI in this recordBook title: Evolutionary Multi-Criterion Optimization7th International Conference on Evolutionary Multi-Criterion Optimization (EMO 2013), Sheffield, UK, March 19-22, 2013The codebase for this paper is available at https://github.com/fieldsend/emo_2013_vizIn this paper two novel methods for projecting high dimensional data into two dimensions for visualisation are introduced, which aim to limit the loss of dominance and Pareto shell relationships between solutions to multi-objective optimisation problems. It has already been shown that, in general, it is impossible to completely preserve the dominance relationship when mapping from a higher to a lower dimension – however, approaches that attempt this projection with minimal loss of dominance information are useful for a number of reasons. (1) They may represent the data to the user of a multi-objective optimisation problem in an intuitive fashion, (2) they may help provide insights into the relationships between solutions which are not immediately apparent through other visualisation methods, and (3) they may offer a useful visual medium for interactive optimisation. We are concerned here with examining (1) and (2), and developing relatively rapid methods to achieve visualisations, rather than generating an entirely new search/optimisation problem which has to be solved to achieve the visualisation– which may prove infeasible in an interactive environment for real time use. Results are presented on randomly generated data, and the search population of an optimiser as it progresses. Structural insights into the evolution of a set-based optimiser that can be derived from this visualisation are also discussed